Quantitative lateralized measures of bradykinesia at different stages of Parkinson's disease: The role of the less affected side
Identifieur interne : 000976 ( Main/Exploration ); précédent : 000975; suivant : 000977Quantitative lateralized measures of bradykinesia at different stages of Parkinson's disease: The role of the less affected side
Auteurs : Stephanie Louie [États-Unis] ; Mandy Miller Koop [États-Unis] ; Anna Frenklach [États-Unis] ; Helen Bronte-Stewart [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-10-15.
English descriptors
Abstract
The onset of motor abnormalities in Parkinson's disease (PD) is usually unilateral. However, current therapeutic trials do not analyze separately the performance of the more affected (MA) and less affected (LA) limbs. From a cohort of 85 subjects at different stages of PD, we asked whether the relationship between bradykinesia and disease severity was similar on both limbs and if the MA side remained more bradykinetic than the LA side in advanced PD. MA and LA limb determination was made from the history of the side first affected. Twenty‐one age‐matched subjects were used as controls. The velocities of finger and arm movements on both sides were inversely correlated with disease severity (P < 0.03). The slope of the decline in wrist movement velocity was steeper on the LA side (P = 0.029). When the regression lines were extrapolated to the y‐axis (UPDRS III = 0) the performance of the LA side was not different from that of controls (P = 0.954 and P = 0.829 for finger and arm movements, respectively), whereas that of the MA side was slower (P = 0.019 and P = 0.016), suggesting that at the theoretical state of no disease the LA side would reflect less or no contralateral nigral pathology. With increasing disease severity, there was less difference between MA and LA sides in both finger and arm bradykinesia (P < 0.004). These findings highlight the value of analyzing separately the MA and LA sides in subjects with PD, especially for clinical trials of potential disease modifying agents in early stages of disease. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22741
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-10-15">2009-10-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="1991">1991</biblScope><biblScope unit="page" to="1997">1997</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">8CDBE15C417F434C2AE84513FE1164C4D72079C5</idno><idno type="DOI">10.1002/mds.22741</idno><idno type="ArticleID">MDS22741</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>bradykinesia</term><term>early stage PD</term><term>fine motor control</term><term>movement velocity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The onset of motor abnormalities in Parkinson's disease (PD) is usually unilateral. However, current therapeutic trials do not analyze separately the performance of the more affected (MA) and less affected (LA) limbs. From a cohort of 85 subjects at different stages of PD, we asked whether the relationship between bradykinesia and disease severity was similar on both limbs and if the MA side remained more bradykinetic than the LA side in advanced PD. MA and LA limb determination was made from the history of the side first affected. Twenty‐one age‐matched subjects were used as controls. The velocities of finger and arm movements on both sides were inversely correlated with disease severity (P < 0.03). The slope of the decline in wrist movement velocity was steeper on the LA side (P = 0.029). When the regression lines were extrapolated to the y‐axis (UPDRS III = 0) the performance of the LA side was not different from that of controls (P = 0.954 and P = 0.829 for finger and arm movements, respectively), whereas that of the MA side was slower (P = 0.019 and P = 0.016), suggesting that at the theoretical state of no disease the LA side would reflect less or no contralateral nigral pathology. With increasing disease severity, there was less difference between MA and LA sides in both finger and arm bradykinesia (P < 0.004). These findings highlight the value of analyzing separately the MA and LA sides in subjects with PD, especially for clinical trials of potential disease modifying agents in early stages of disease. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Louie, Stephanie" sort="Louie, Stephanie" uniqKey="Louie S" first="Stephanie" last="Louie">Stephanie Louie</name></region><name sortKey="Bronte Tewart, Helen" sort="Bronte Tewart, Helen" uniqKey="Bronte Tewart H" first="Helen" last="Bronte-Stewart">Helen Bronte-Stewart</name><name sortKey="Bronte Tewart, Helen" sort="Bronte Tewart, Helen" uniqKey="Bronte Tewart H" first="Helen" last="Bronte-Stewart">Helen Bronte-Stewart</name><name sortKey="Frenklach, Anna" sort="Frenklach, Anna" uniqKey="Frenklach A" first="Anna" last="Frenklach">Anna Frenklach</name><name sortKey="Koop, Mandy Miller" sort="Koop, Mandy Miller" uniqKey="Koop M" first="Mandy Miller" last="Koop">Mandy Miller Koop</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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